Making a more bioavailable fisetin
When you ingest fisetin, enzymes in your digestive
system soon break it down to various metabolites. To
shield it from being quickly broken down, we’ve
combined fisetin with galactomannan fibers from
fenugreek seeds, a technique we pioneered with our
Curcumin Elite™ formula. Doing so preserves fisetin
through your digestive system, allowing it to
circulate: Bio-Fisetin is up to 25 times more
bioavailable than standard fisetin supplements.
Why Should I Supplement with Bio-Fisetin?
Have you ever thought about supporting your health and
youthfulness at the cellular level?
It's possible, and better yet, we know one of the
secrets: fisetin. Found in fruits and vegetables,
fisetin is an antioxidant that encourages the natural
clearing of senescent cells. You know, the ones that
have outlived their usefulness. But, it's hard for the
body to absorb. That's why Life Extension’s experts
optimized our Bio-Fisetin formula to be up to 25 times
more bioavailable.
That means it circulates in your body longer, so you're
getting the maximum benefits. What are those benefits?
Fisetin supports your brain health, cellular health,
longevity, and more. Optimize your health support at
the cellular level with Bio-Fisetin from Life
Extension.
By combining fisetin with fenugreek fibers, we’re able
to create a fisetin formula that is up to 25 times more
bioavailable. This means that the fisetin in our
Bio-Fisetin supplement circulates longer than
traditional fisetin. So what good can all that extra
time with fisetin do for your body? As it turns out,
quite a bit!
Fisetin and cellular senescence
Cellular senescence is a natural part of the aging
process in which cells no longer function
optimally. Senescent cells can accumulate over
time, affecting the day-to-day function of the
healthy cells around them. Fortunately, fisetin is
a senolytic compound—an ingredient that actively
targets senescent cells.
In fact, fisetin is among the strongest senolytic
compounds discovered so far. Fisetin helps
encourage the body’s natural pathways for clearing
senescent cells, which allows healthy cells to
flourish.1 Another important aspect of cellular
longevity is sirtuin function. Sirtuin proteins
keep your cells performing at their best—but
sirtuin activity declines with age. Fisetin has
been shown in preclinical studies to encourage
youthful, healthy sirtuin function.2-6
Fisetin and brain health
Protecting your brain is another good way to live
longer. A recent clinical trial showed that fisetin
helped protect the delicate nerve cells in the
brain, and it has also shown promise for
encouraging healthy cognitive function in
preclinical studies.7-9 The key is absorbing enough
fisetin for it to matter.
Fisetin and glucose metabolism
Glucose metabolism is important for everything from
kidney function to how your body gains or loses
weight. But maintaining already-healthy blood sugar
can get harder as we get older. Studies indicate
that fisetin acts as a kind of metabolism control
switch, which may help your body maintain healthy
glucose levels already within normal range.10,11
This in turn helps promote kidney health and vision
health.
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