What Is TMG?
Trimethylglycine (TMG) has been linked to heart health by
supporting already-healthy homocysteine levels to promote
healthy cardiovascular function. By having a positive impact on
your homocysteine levels, TMG helps you stay healthy by
supporting multiple systems throughout your body.
TMG (also called glycine betaine) has been associated with
beneficial effects on liver function and cardiovascular health.
TMG Benefits
-
Promotes healthy homocysteine levels already within normal
range
-
Helps inhibit inflammatory factors to encourage
cardiovascular health
-
Supports already-healthy blood pressure levels
-
Encourages whole-body health
-
Helps maintain healthy mitochondrial function
Over 50 Years of Research
Trimethylglycine has been known as a heart-healthy amino
acid compound since the 1950s. That’s more than 50 years of
scientific research to rely upon.
Product Details
Trimethylglycine (TMG) is also called glycine betaine,
but the name trimethylglycine signifies that it has
three methyl groups attached to each molecule of
glycine. Wheat bran is the main dietary source of TMG,
with smaller amounts available in other cereal grains.1
TMG can also be made in the body from choline, an
essential nutrient found in eggs, soybeans and many
other foods.2,3
TMG was found to be beneficial to heart health in
the 1950s.4-6 Like some of the B vitamins (B6, B12
and folate), TMG is a methyl donor, providing extra
methyl groups to hasten the conversion of
homocysteine back to methionine. When a TMG methyl
group is donated to a molecule of homocysteine, it
converts it to the non-toxic amino acid,
methionine.7
The role of TMG in healthy homocysteine metabolism
is even more important when B vitamin levels are
low.8 Some evidence suggests TMG may be more
efficient at regulating homocysteine levels than
folate. 9 Research showing TMG's ability to promote
healthy levels of homocysteine already within
normal range, alone or in conjunction with other
nutrients, confirms its status as an important
nutrient for cardiovascular and overall health.7,9
TMG has been associated with healthy blood pressure
and mitochondrial function, and has been found to
be linked to cardiovascular health.2,10-12 TMG has
also been found to promote healthy liver
function.13 Studies show TMG can support a healthy
inflammatory response by inhibiting expression of
NFkappaB, TNF-alpha, and other inflammatory
proteins, which may partially explain its positive
impacts.14 Because intestinal microbes can make
various by-products from TMG, the health of the gut
microbiome influences the effects of TMG in the
body.15,16
- Foods
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ARYA Atheroscler
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Am J Clin Nutr
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Ann West Med Surg
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Ann West Med Surg
. 1951;5(10):830-855.
-
Ann West Med Surg
. 1951;5(10):863-875.
-
J Inherit Metab Dis
. 2011;34(1):3-15.
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Am J Clin Nutr
. 2010;91(5):1303-10.
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Curr Opin Clin Nutr Metab Care
. 2013;16(1):102-108.
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J Clin Hypertens (Greenwich)
. 2018;20(2):388-393.
-
Biochem Biophys Res Commun
. 2015;456(2):621-625.
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PLoS One
. 2014;9(12):e114969.
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Vet Res Forum
. 2018;9(2):129-135.
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Molecules
. 2018;23(6)
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Eur Heart J
. 2014;35(14):904-910.
-
Microbiome
. 2019;7(1):103.
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