B Vitamins May Reduce Cervical Cancer Risk
LifeSource Vitamins
Although cervical cancer only comprises 1.5% of all cancers in women and
the incidence has steadily declined by approximately 2% per year since
1955, it can be fatal if it is not detected in time. The decrease in
cervical cancer has primarily been attributed to the the Pap smear now used
to detect early abnormal changes in the cells of the cervix. Risk factors
for cervical cancer include smoking, oral contraceptive use, a diet low in
fruits and vegetables, and a family history of cervical cancer. Infection
with human papilloma virus (HPV; a sexually transmitted virus that causes
genital warts and is associated with causing cervical dysplasia), or other
sexually transmitted diseases such as chlamydia, also increases a woman's
risk of developing cervical cancer. Increasing the intake of B vitamins may
help prevent women from having to undergo surgery to treat either cervical
dysplasia or cancer.
In the new study, 214 women aged 18 years and older with low- or high-grade
cervical dysplasia and 270 healthy women completed questionnaires regarding
their typical daily diet. (The grade of dysplasia represents the degree to
which the cells of the cervix have abnormally changed. High-grade dysplasia
suggests the cells are closer to becoming cervical cancer, while low-grade
dysplasia indicates that the cervical cells have undergone abnormal
changes, but not to the same extent as seen with high-grade dysplasia.) The
frequency and quantity of all foods, alcohol, and nutritional supplements
consumed were recorded. Specific nutrient levels were calculated based on
intake from food alone, supplements alone, and food and supplements
combined. Each woman was also tested for HPV infection.
More than 70% of the women diagnosed with cervical dysplasia were infected
with HPV, compared with 10% without cervical dysplasia. HPV infection was
more associated with high-grade cervical dysplasia than low-grade cervical
dysplasia. Higher intake of vitamins B1 and B2 from food sources, vitamin
B12 from supplements, and total folic acid (from food and supplements) was
associated with a decreased risk of developing high-grade cervical
dysplasia. Low-grade cervical dysplasia risk decreased as intake of vitamin
B2 from food and total folic acid increased. The risk dropped by 50 to 90%
for the highest intake of these nutrients, compared with the lowest intake.
A significant increase in high-grade cervical dysplasia was observed in
smokers or alcohol drinkers (even in small quantities) with low levels of B
vitamins, compared with nonsmokers and nondrinkers with high intakes of
these nutrients.
The authors of the current study suggest that HPV infection may be
associated with low nutrient intake of B vitamins and that women who are
relatively depleted of these vitamins may be more susceptible to cervical
dysplasia. Studies have shown that oral contraceptive pills deplete the
body of B vitamins and their use is known to increase the risk of cervical
dysplasia, adding support to this theory. However, studies have yet to
clearly show that this is true. Nonetheless, B vitamins are relatively safe
and inexpensive and may add to the arsenal of nutrients to prevent cancer.
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Healthnotes Newswire (February 26, 2004)- Women with low dietary intakes of
vitamins B1 (thiamine), B2 (riboflavin), B12 (cobalamin), and folic acid
may be more at risk of developing premalignant changes in the cervix
(called cervical dysplasia), according to a new study in Cancer Causes and
Control (2003;14:859-70). The findings suggest that increasing the intake
of these vitamins may help prevent the development of cervical cancer.
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