Chromium Supplement Shown Effective for Common Depression
LifeSource Vitamins
Atypical depression, one of the most common forms of depression, is
characterized by mood reactivity (increased sensitivity to being rejected
by another person and improved mood when something good happens), increased
appetite, excessive sleepiness, and sluggishness. Compared with other forms
of depression, atypical depression tends to persist longer and is
associated with more thoughts of suicide and greater disability.
Chromium is an essential trace mineral that plays a role in regulating
blood sugar by enhancing the action of insulin. In people with a common
blood-sugar-regulation disorder known as reactive hypoglycemia, chromium
supplementation prevents the excessive decline in blood-sugar levels and
decreases the associated symptoms. Chromium also influences the sensitivity
of certain receptors on brain cells that help control a person's mood. In
previous studies, chromium supplementation was beneficial for people
suffering from dysthymia, a mood disorder related to depression.
The symptoms of atypical depression overlap with those associated with
reactive hypoglycemia. If atypical depression is a manifestation of
reactive hypoglycemia in some people, then chromium supplementation might
be helpful for them.
In the new study, 75 people with atypical depression, most of whom were
overweight or obese, received either 600 mcg per day of chromium (as
chromium picolinate) or a placebo for eight weeks. The proportion of people
who improved by at least 50% (responders) was greater in the chromium group
than in the placebo group (54% versus 36%), although this difference was
not statistically significant. However, significant differences were seen
when the analysis was restricted to those people who reported that they had
severe carbohydrate craving (a possible indicator of abnormal glucose
metabolism). In that subset, the proportion of responders was 65% in the
chromium group and only 33% in the placebo group, a statistically
significant difference. No significant side effects were observed in people
taking chromium.
The results of this study indicate that people with atypical depression who
also crave carbohydrates are likely to improve if they take 600 mcg of
chromium per day. If chromium works by improving blood-glucose regulation,
then its effects might be enhanced by dietary changes (avoiding refined
sugar, caffeine, and alcohol, and eating small, frequent meals) and by
supplementing with other blood-glucose-stabilizing nutrients, including B
vitamins, magnesium, zinc, and copper. Regular aerobic exercise may also
relieve depression, possibly by improving insulin sensitivity and
blood-sugar control.
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Healthnotes Newswire (December 8, 2005)-
Chromium supplements can relieve symptoms in some patients suffering
from one type of depression (atypical depression), reports the Journal
of Psychiatric Practice (2005;11:302-14).
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