Coenzymated B-Complex — Coenzymated B-Vitamins, Vegetarian Capsules — Supports Energy Metabolism & Cognitive Function*
Lifesource Vitamins Coenzymated B-Complex delivers bioactive, coenzymated B-vitamins (Thiamin, Riboflavin-5′-phosphate, Niacin/Niacinamide, Pyridoxal-5′-phosphate, Folate [5-MTHF], Methylcobalamin B-12, Biotin, Pantothenic Acid) with Choline in a vegetarian capsule to support energy metabolism, nervous system health, and healthy homocysteine metabolism. Produced in FDA-registered, GMP-certified facilities for quality assurance.*
Research-Driven & Verified Product.
Explore the clinical research, ingredient science, and global evidence supporting this product below.
Research Promise: At LifeSource Vitamins, our commitment is rooted in research and results. Every benefit below is supported by human clinical studies indexed in the National Institutes of Health (NIH) via PubMed, with full texts available in the National Library of Medicine (NLM) PubMed Central (PMC) when available. In addition, we reference reviews from leading health organizations and insights from top global universities to ensure our guidance aligns with credible science.*
Clinically Studied Benefits
✓ Corrects B-12 deficiency (hematologic & neurologic) — High-dose oral cobalamin was as effective as intramuscular therapy in randomized clinical trials of B-12 deficiency.
NIH/PubMed — Kuzminski, 1998
✓ Raises serum B-12 & improves functional markers — Oral high-dose B-12 increased serum cobalamin and reduced methylmalonic acid/homocysteine versus low dose/placebo (randomized evidence).
NIH/PubMed — Vidal-Alaball, 2005
✓ Homocysteine & brain atrophy (MCI subgroup) — In older adults with mild cognitive impairment and elevated homocysteine, folate+B-6+B-12 slowed whole-brain atrophy vs placebo (double-blind RCT).
NIH/PubMed — Smith, 2010
✓ Cognition in low-folate elders — Three-year folic acid (with stable B-12 status) improved memory and processing speed vs placebo (DB-RCT).
NIH/PubMed — Durga, 2005
✓ Stress & mood in healthy but stressed adults — B-complex formulations reduced perceived stress and improved mood/well-being (randomized, placebo-controlled).
NIH/PubMed — Stough, 2014
Additional / Promising Evidence
✓ Coenzymated vs. non-coenzymated forms — Active (e.g., P-5-P, R-5-P, methylcobalamin, 5-MTHF) forms participate directly in metabolism; however, head-to-head human trials versus standard forms for clinical outcomes are limited. Use to support individuals needing activated forms under clinician guidance.
NIH/PubMed — Kuzminski, 1998
✓ Homocysteine lowering & major CVD events — Although B-vitamins lower homocysteine, large outcome RCTs did not reduce major cardiovascular events.
NIH/PubMed — HOPE-2, 2006
✓ Choline & cognition — Choline is a precursor to acetylcholine and supports liver/brain function; robust benefits are clearest in deficiency states. High-quality RCTs in generally healthy adults remain limited.
NIH/PubMed — Stough, 2014
University-Led & Academic Studies
✓ Corrects B-12 deficiency (hematologic & neurologic) — High-dose oral cobalamin was as effective as intramuscular therapy in randomized clinical trials of B-12 deficiency.
NIH/PubMed — Kuzminski, 1998
✓ Raises serum B-12 & improves functional markers — Oral high-dose cobalamin increased serum cobalamin and reduced methylmalonic acid/homocysteine versus low dose/placebo (randomized evidence).
NIH/PubMed — Vidal-Alaball, 2005
✓ Homocysteine & brain atrophy (MCI subgroup) — In older adults with mild cognitive impairment and elevated homocysteine, folate+B-6+B-12 slowed whole-brain atrophy vs placebo (double-blind RCT).
NIH/PubMed — Smith, 2010
✓ Cognition in low-folate elders — Three-year folic acid (with stable B-12 status) improved memory and processing speed vs placebo (DB-RCT).
NIH/PubMed — Durga, 2005
✓ Stress & mood in healthy but stressed adults — B-complex formulations reduced perceived stress and improved mood/well-being (randomized, placebo-controlled).
NIH/PubMed — Stough, 2014
Global Evidence & Reviews
✓ NIH ODS — Vitamin B12 — Health-professional fact sheet on roles, deficiency, supplementation, and safety.
NIH/ODS — Vitamin B12
We monitor research from leading institutions —
Harvard, Johns Hopkins, Mayo Clinic, Cleveland Clinic, Cambridge, Oxford, Stanford, Yale, Tufts, University of Florida, Oregon State University – Linus Pauling Institute, Columbia, Cornell, Ohio State — to align with credible science.*
Key Ingredients
-
Vitamin B-12 (Methylcobalamin) — Bioactive form supporting energy metabolism, nervous system health, red blood cell production, and healthy homocysteine metabolism. (NIH/PubMed — Kuzminski, 1998; NIH/PubMed — Smith, 2010)
-
Folate (5-MTHF) — Required for one-carbon metabolism and DNA synthesis; with B-12 helps normalize homocysteine. Cognitive benefits shown in specific older populations with low folate or elevated homocysteine. (NIH/PubMed — Durga, 2005; NIH/PubMed — Smith, 2010)
-
Vitamin B-6 (Pyridoxal-5′-Phosphate) — Cofactor in neurotransmitter synthesis; supports mood and brain health (human data). (NIH/PubMed — Stough, 2014)
-
Choline (Choline Bitartrate) — Acetylcholine precursor supporting cognitive function; most impactful where intake is inadequate.
Brief Benefit Bullets
- Powers energy metabolism for daily vitality*
- Supports cognitive function & healthy brain aging (in select older adults with elevated homocysteine)*
- Supports nervous system health & neurotransmitter pathways*
- Helps maintain healthy homocysteine metabolism*
- Supports red blood cell formation to help prevent megaloblastic anemia (with adequate B-12/folate)*
- Promotes stress resilience and mood in healthy but stressed adults*
-
3rd-party lab tested for purity & potency
Suggested Use
Take 1 capsule daily with a meal, or as directed by your healthcare professional. Do not exceed recommended dose. If pregnant, nursing, taking medications, or have a medical condition, consult your physician.*
Product Specifications
• Serving Size — 1 Capsule
• Form — Vegetarian Capsules
• Free From — Non-GMO, gluten-free, vegan; no artificial colors, flavors, or preservatives*
• Quality — Third-party tested for identity, potency & purity
LifeSource Vitamins — Proudly American — Since 1992
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Coenzymated B-Complex — activated B-vitamins supporting energy, nerves, and healthy homocysteine. Clinically Studied Ingredients — NIH/PubMed!*
