Vitamin B-12 Methylcobalamin 5000 mcg w/ Folate 600 mcg DFE — 60 Lozenges — Supports Energy Metabolism & Nervous System Health*
Lifesource Vitamins Vitamin B-12 Methylcobalamin 5000 mcg delivers high-potency, bioactive methylcobalamin in a sublingual lozenge to support energy metabolism, nervous system health, mental clarity, and healthy homocysteine metabolism. Produced in FDA-registered, GMP-certified facilities for quality assurance.*
Research-Driven & Verified Product.
Explore the clinical research, ingredient science, and global evidence supporting this product below.
Research Promise: At LifeSource Vitamins, our commitment is rooted in research and results. Every benefit below is supported by human clinical studies indexed in the National Institutes of Health (NIH) via PubMed, with full texts available in the National Library of Medicine (NLM) PubMed Central (PMC) when available. In addition, we reference reviews from leading health organizations and insights from top global universities to ensure our guidance aligns with credible science.*
Clinically Studied Benefits
✓ Corrects B-12 deficiency (hematologic & neurologic) — High-dose oral cobalamin is as effective as intramuscular therapy in randomized trials of deficiency (pernicious anemia/food-cobalamin malabsorption). NIH/PubMed — Kuzminski, 1998
✓ Raises serum B-12 & improves biomarkers — Oral high-dose cobalamin significantly increases serum B-12 and lowers methylmalonic acid/homocysteine vs placebo/low dose. NIH/PubMed — Vidal-Alaball, 2005
✓ Homocysteine & brain atrophy (MCI subgroup) — In older adults with mild cognitive impairment and elevated homocysteine, folate+B-6+B-12 slowed whole-brain atrophy vs placebo (double-blind RCT). NIH/PubMed — Smith, 2010
✓ Cognition in low-folate elders — Three-year folic acid (with stable B-12 status) improved memory and information processing (DB-RCT). NIH/PubMed — Durga, 2005
✓ Symptom relief in deficiency — Oral cobalamin regimens corrected anemia and neurologic findings comparably to injections in clinical trials. NIH/PubMed — Kuzminski, 1998
✓ Stress & mood in healthy but stressed adults — B-complex formulations (including B-12) reduced perceived stress and improved mood/well-being (randomized, placebo-controlled). NIH/PubMed — Stough, 2014
Additional / Promising Evidence
✓ Homocysteine lowering & major CVD events — Although B-vitamins (including B-12) lower homocysteine, large outcome RCTs did not reduce major cardiovascular events. NIH/PubMed — HOPE-2, 2006
✓ Neuropathy & methylcobalamin — Human studies suggest benefit in some neuropathies, but dosing/forms and trial quality vary; more robust RCTs are needed. Avoid disease claims without provider guidance. NIH/PubMed — Kuzminski, 1998
University-Led & Academic Studies
✓ Corrects B-12 deficiency (hematologic & neurologic) — High-dose oral cobalamin is as effective as intramuscular therapy in randomized trials of deficiency (pernicious anemia/food-cobalamin malabsorption). NIH/PubMed — Kuzminski, 1998
✓ Raises serum B-12 & improves biomarkers — Oral high-dose cobalamin significantly increases serum B-12 and lowers methylmalonic acid/homocysteine vs placebo/low dose. NIH/PubMed — Vidal-Alaball, 2005
✓ Homocysteine & brain atrophy (MCI subgroup) — In older adults with mild cognitive impairment and elevated homocysteine, folate+B-6+B-12 slowed whole-brain atrophy vs placebo (double-blind RCT). NIH/PubMed — Smith, 2010
✓ Cognition in low-folate elders — Three-year folic acid (with stable B-12 status) improved memory and information processing (DB-RCT). NIH/PubMed — Durga, 2005
✓ Symptom relief in deficiency — Oral cobalamin regimens corrected anemia and neurologic findings comparably to injections in clinical trials. NIH/PubMed — Kuzminski, 1998
Global Evidence & Reviews
✓ NIH ODS — Vitamin B12 — Health-professional fact sheet on roles, deficiency, supplementation, and safety. NIH/ODS — Vitamin B12
We monitor research from leading institutions — Harvard, Johns Hopkins, Mayo Clinic, Cleveland Clinic, Cambridge, Oxford, Stanford, Yale, Tufts, University of Florida, Oregon State University – Linus Pauling Institute, Columbia, Cornell, Ohio State — to align with credible science.*
Key Ingredients
Brief Benefit Bullets
- Powers energy metabolism for daily vitality*
- Supports nervous system health & myelin integrity*
- Promotes red blood cell formation to help prevent megaloblastic anemia*
- Helps maintain healthy homocysteine metabolism*
- Sparks mental clarity in B-12–deficient individuals*
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3rd-party lab tested for purity & potency
Suggested Use
Place 1 lozenge under the tongue daily and allow it to fully dissolve, or as directed by your healthcare professional. Do not exceed recommended dose. If pregnant, nursing, taking medications, or have a medical condition, consult your physician.*
Product Specifications
• Serving Size — 1 Lozenge
• Servings Per Container — 60
• Form — Sublingual Lozenge
• Free From — Non-GMO, gluten-free, vegan*
• Quality — Third-party tested for identity, potency & purity
LifeSource Vitamins — Proudly American — Since 1992
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Vitamin B-12 Methylcobalamin 5000 mcg lozenges — supports energy metabolism, nervous system & healthy homocysteine. Clinically Studied Ingredients — NIH/PubMed!*
