Milk Thistle — 90 Capsules — Supports Healthy Liver Enzymes, Antioxidant Defense & Metabolic Balance*
LifeSource Vitamins Milk Thistle (Silymarin) provides a standardized extract from Silybum marianum to support healthy liver enzyme balance, cellular antioxidant defenses, and everyday wellness. Produced in FDA-registered, GMP-certified facilities and 3rd-party tested for identity, potency & purity.*
Research-Driven & Verified Product.
Explore the clinical research, ingredient science, and global evidence supporting this product below.
Research Promise: At LifeSource Vitamins, our commitment is rooted in research and results. Every benefit below is supported by human clinical studies indexed in the National Institutes of Health (NIH) via PubMed, with full texts available in the National Library of Medicine (NLM) PubMed Central (PMC) when available. We also reference reviews from 39 leading health organizations and insights from 20 top global universities to keep our guidance aligned with credible, evidence-based science.* Every claim is supported by peer-reviewed human RCTs or meta-analyses whenever available.
Clinically Studied Benefits
✓ Liver enzymes in NAFLD — Silybin–phosphatidylcholine + vitamin E improved ALT and metabolic markers.
NIH/PubMed — Loguercio, 2012
✓ Insulin resistance & liver damage in NAFLD — Silybin–vitamin E–phospholipid complex showed improvements.
NIH/PubMed — Federico, 2006
✓ NASH (high-dose silymarin) — Safety confirmed; exploratory fibrosis signals; mixed primary endpoints.
NIH/PubMed — Navarro, 2019
✓ NASH 48-week RCT — Primary NAS endpoint not met; well-tolerated; possible antifibrotic signal.
NIH/PubMed — Kheong, 2017
✓ Type 2 Diabetes — 4-month RCT improved glycemic profile vs placebo.
NIH/PubMed — Huseini, 2006
✓ T2D adjunct — Added to glibenclamide improved glycemic control in 120-day RCT.
NIH/PubMed — Hussain, 2007
✓ Diabetic nephropathy — Reduced albuminuria vs placebo on RAS blockade.
NIH/PubMed — Fallahzadeh, 2012
✓ Acute viral hepatitis — RCT assessed symptoms, labs, safety; generally well-tolerated.
NIH/PubMed — El-Kamary, 2009
✓ Chronic HCV (high-dose) — No ALT benefit vs placebo; high-dose safety characterized.
NIH/PubMed — Fried, 2012
✓ Alcohol-related cirrhosis (oxidative markers) — ↑GSH, ↓lipid peroxidation vs placebo at 6 months.
NIH/PubMed — Lucena, 2002
Additional / Promising Evidence
✓ NAFLD meta-analysis — Pooled RCTs associate silymarin with ALT/AST reductions.
NIH/PubMed — Zhong, 2017
✓ NAFLD systematic review (2024) — Signals for enzyme and histology improvements; calls for larger RCTs.
NIH/PubMed — Li, 2024
✓ Chronic liver disease RCT (2024) — Reduced ALT/AST vs standard care; stronger effects in metabolic liver disease.
NIH/PubMed — Amjad, 2024
✓ Diabetes & lipids review — Summarizes glycemic and lipid findings; safety profile.
NIH/PubMed — Xiao, 2020
University-Led & Academic Studies
✓ University of Naples (Italy) — NAFLD improvements with silybin–vitamin E–phospholipids.
NIH/PubMed — Federico, 2006
✓ NIH-funded U.S. centers — High-dose silymarin studies in NASH/HCV clarified safety & histology endpoints.
NIH/PubMed — Navarro, 2019
✓ University of Granada (Spain) — Antiperoxidative effects in alcoholic cirrhosis RCT.
NIH/PubMed — Lucena, 2002
✓ University of Tehran & collaborators — T2D RCTs reporting glycemic benefits.
NIH/PubMed — Huseini, 2006
Global Evidence & Reviews
✓ World Health Organization (WHO) — Monograph on Silybum marianum (quality, safety, usage context).
WHO PDF
✓ European Medicines Agency (EMA/HMPC) — Assessment report for milk thistle fruit preparations.
EMA PDF
✓ NCCIH (NIH) — Milk thistle fact sheet (mixed evidence, safety notes, research gaps).
NCCIH
We monitor research from leading institutions —
Harvard, Johns Hopkins, Mayo Clinic, Cleveland Clinic, Cambridge, Oxford, Stanford, Yale, Tufts, University of Florida, Oregon State University – Linus Pauling Institute, Columbia, Cornell, Ohio State — to align with credible science.*
Key Ingredients
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Milk Thistle Extract — Concentrated flavonolignans that support antioxidant defenses and healthy liver enzyme balance.*
Brief Benefit Bullets
- Supports healthy liver enzyme balance (ALT/AST) in adults*
- Helps defend cells from oxidative stress*
- Supports metabolic balance and everyday wellness*
- Gentle, well-tolerated herbal support*
- 3rd-party lab tested for identity, potency & purity*
Suggested Use
See product label for full instructions, or as directed by your healthcare professional. Do not exceed recommended dose. If pregnant, nursing, taking medications, or have a medical condition, consult your physician.*
Product Specifications
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Form: Easy-to-swallow capsules
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Serving Size: See Supplement Facts label
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Servings Per Container: See Supplement Facts label
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Free From: Non-GMO, gluten-free; no artificial colors, preservatives or synthetic chemicals*
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Quality: Third-party tested for identity, potency & purity
LifeSource Vitamins — Proudly American — Since 1992
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Silymarin (Milk Thistle) — supports healthy liver enzymes, antioxidant defense & metabolic balance. 3rd-party tested quality. Clinically Studied Ingredients — NIH/PubMed!*
