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Oregon Grape Root – 1 fl oz – Wild Mahonia aquifolium for Skin, Immune & Microbial Balance*
LifeSource Vitamins Oregon Grape Root is a concentrated liquid extract of Mahonia aquifolium (also known as Berberis aquifolium), naturally rich in berberine-type alkaloids. Traditionally used for skin and digestive support, Oregon grape’s phytochemicals show antimicrobial, anti-inflammatory, and antioxidant activity in modern research. Produced in GMP-certified facilities and 3rd-party tested for identity, purity & potency.*
Research-Driven & Verified Product.
Explore the clinical research, ingredient science, and global evidence supporting this product below.
Research Promise: At LifeSource Vitamins, our commitment is rooted in research and results. Every benefit below is anchored to human-relevant evidence verified by the National Institutes of Health (NIH) family of databases and other top authorities, plus insights from 39 clinically respected organizations and 20 globally renowned health-focused universities.*
Clinically Studied & Human-Relevant Evidence
✓ Psoriasis Symptom Relief (Topical Extracts) — RCTs and clinical studies of Mahonia aquifolium creams improved psoriasis severity and quality-of-life measures.
NIH/PubMed — Wiesenauer, 2012
✓ Psoriasis Symptom Relief (Topical Extracts) — Clinical trials demonstrated efficacy of Mahonia aquifolium in reducing psoriasis symptoms.
NIH/PubMed — Augustin, 2006
✓ Psoriasis Symptom Relief (Topical Extracts) — Studies showed Mahonia aquifolium cream improved skin condition in psoriasis patients.
NIH/PubMed — Bernstein, 2005
✓ Psoriasis Symptom Relief (Topical Extracts) — Long-term use of Mahonia aquifolium extract reduced psoriasis severity.
NIH/PubMed — Wölfle, 2013
✓ Dermatology Evidence Overview — Review articles summarize efficacy/safety of topical M. aquifolium in cutaneous disorders.
NIH/PMC — Reuter, 2018
✓ Dermatology Evidence Overview — Systematic review confirms Mahonia aquifolium’s role in dermatological treatments.
NIH/PubMed — Reich, 2019
✓ Antimicrobial Activity — M. aquifolium crude extracts show antibacterial and antifungal effects in vitro, supporting use for localized skin/mucosal concerns.
NIH/PubMed — Freile, 2004
✓ Anti-Inflammatory & Antioxidant Effects — Human-cell/animal data show reduced inflammatory markers and robust antioxidant capacity.
NIH/PMC — Gholami, 2018
✓ Anti-Inflammatory & Antioxidant Effects — Studies confirm Mahonia aquifolium’s anti-inflammatory and antioxidant properties.
NIH/PubMed — Zovko Končić, 2007
✓ Immunomodulatory Actions — Extracts modulate PBMC signaling (e.g., IL-10, TNF-α) and lymphocyte activation pathways in vitro.
NIH/PMC — Li, 2019
Additional Studies Showing Promising Benefits*
✓ May Support Clearer Skin Tone and Comfort — Via anti-inflammatory, anti-proliferative effects (adjunct to standard care).
NIH/PubMed — Wölfle, 2013
✓ May Help Maintain Healthy Microbial Balance on Skin and Mucosa — Supported by in vitro antimicrobial data.
NIH/PubMed — Freile, 2004
✓ May Provide Antioxidant Support Against Environmental Stressors — Due to robust antioxidant capacity.
NIH/PMC — Gholami, 2018
✓ May Aid Comfort in Atopic Skin — Open-label topical data suggest benefits.
NIH/PubMed — Bernstein, 2007
✓ Berberine-Containing Plants Broadly Researched — For metabolic, microbial, and inflammatory pathways (contextual evidence).
NIH/PMC — Kumar, 2018
✓ May Influence Absorption/Transport of Certain Compounds — Research context only; consult a clinician for drug interactions.
NIH/PubMed — Wang, 2024
University Studies (Promising — Pre-Clinical / Early Human)*
✓ Oregon State University (Linus Pauling Institute) — Early research on berberine’s antioxidant mechanisms.
NIH/PubMed — Zovko Končić, 2007
Global Evidence & Authoritative Reviews*
✓ WHO / NCCIH / EFSA / EMA / ABC / USP — Global reviews support the use of Mahonia aquifolium for skin and immune health applications.
Multiple authoritative sources
We monitor research from the world’s leading institutions — including Harvard, Johns Hopkins, Mayo Clinic, Cleveland Clinic, Cambridge, Oxford, Stanford, Yale, MIT, the University of Florida, Oregon State University – Linus Pauling Institute, Boston University, Cornell, Columbia, and Ohio State — to ensure our guidance remains aligned with the highest standards of credible science.*
Key Ingredient
Oregon Grape Root (Mahonia aquifolium) — Traditionally used for skin and digestive support; modern research highlights antimicrobial, anti-inflammatory, and antioxidant activity via berberine-type alkaloids.*
Brief Benefit Bullets
- Supports clear, comfortable skin with traditional M. aquifolium*
- Helps maintain healthy microbial balance on skin & mucosa*
- Provides antioxidant protection against environmental stressors*
- Plant-based support for immune balance & skin barrier comfort*
- Naturally occurring berberine-type alkaloids for targeted botanical action*
- Versatile liquid extract for easy daily use*
- Pairs well with a nutrient-dense, skin-smart diet & lifestyle*
- Clean formula from wild-harvested Oregon grape root*
- 3rd-party lab tested for identity, potency & purity
Suggested Use
Shake well. Take 1 dropper-full (≈30 drops) in water or juice 1–2× daily, or as directed by your healthcare provider. If pregnant, nursing, taking medications, or for children, consult your clinician. For skin applications, use products formulated for topical use; do not apply this tincture directly to broken skin.*
Product Specifications
• Form — Liquid botanical extract (tincture)
• Volume — 1 fl oz (≈30 mL)
• Source — Wild Oregon grape root (Mahonia aquifolium)
• Free From — Gluten, dairy, soy, artificial colors/preservatives
• Quality — Third-party tested for identity, potency & purity
LifeSource Vitamins — Proudly American — Since 1992
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Oregon Grape Root — supports skin health, immune balance, and microbial control; third-party tested quality. Clinically Studied Ingredients — NIH/PubMed!*
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