LifeSource Vitamins Progesterone Balancing Skin Cream — Natural 20 mg per Pump, 3 oz — Bio-Identical Hormonal & Skin Support for Women*
LifeSource Vitamins Progesterone Balancing Skin Cream combines USP bio-identical progesterone derived from wild yam with complementary Botanicals to support skin elasticity, wrinkle reduction, and hormonal balance in peri- and post-menopausal women. Produced in FDA-registered, GMP-certified facilities and 3rd-party tested for identity, potency & purity.*
Research-Driven & Verified Product.
Explore the clinical research, ingredient science, and global evidence supporting this product below.
Research Promise: At LifeSource Vitamins, our commitment is rooted in research and results. Every benefit below is supported by human clinical studies indexed in the National Institutes of Health (NIH) via PubMed, with full texts available in the National Library of Medicine (NLM) PubMed Central (PMC) when available. In addition, we reference reviews from 39 respected health organizations and insights from 20 leading universities worldwide to ensure our guidance aligns with credible science.*
Clinically Studied Benefits
✓ Improved skin elasticity & firmness — A double-blind, randomized vehicle-controlled trial showed topical 2% progesterone cream significantly increased skin firmness (+23.6% vs +13.2% control). NIH/PubMed — Holzer, 2005
✓ Reduced wrinkle count & depth — The same RCT found wrinkle counts decreased 29.1% with progesterone cream vs 16.5% with placebo; depth also reduced in eye/nasolabial regions. NIH/PubMed — Holzer, 2005
✓ Hormonal balance safety — Natural micronized progesterone shows favorable tolerability compared with synthetic progestins in peri- and post-menopausal hormone therapy. NIH/PubMed — Gasser, 2021
✓ Transdermal absorption — Human pharmacokinetic studies confirm measurable rises in serum progesterone after topical application, demonstrating absorption. NIH/PubMed — Stanczyk, 2005
✓ Skin distribution — In vitro distribution studies show topical progesterone penetrates skin layers effectively. NIH/PMC — Banov, 2024
✓ Absorption across sites — Older pharmacology studies confirmed percutaneous absorption of progesterone, with higher uptake across breast skin vs forearm. NIH/PubMed — Krause, 1987
✓ Anti-aging support — Reviews note progesterone cream improves viscoelasticity and collagen structure in skin of menopausal women. NIH/PMC — Stevenson, 2007
✓ Collagen stimulation — Hormone therapy including progesterone stimulates fibroblast activity and type I collagen production, reducing dermal thinning. NIH/PMC — Pivazyan, 2023
✓ Skin aging reviews — Comprehensive analyses show topical progesterone is among the hormonal options linked to reduced wrinkle depth and improved hydration in peri- and post-menopausal women. NIH/PubMed — Gasser, 2021
✓ Well tolerated — Clinical and pharmacokinetic studies consistently report natural progesterone cream is safe with minimal side effects in women. NIH/PubMed — Holzer, 2005
Additional Studies Showing Promising Benefits*
✓ Menopausal symptom relief — Wild yam cream has been tested for tolerability in menopausal women; generally safe, though symptom reduction was not significant vs placebo. NIH/PubMed — Komesaroff, 2001
✓ Hormone therapy reviews — Broader reviews of menopausal hormone therapy note skin rejuvenation potential of combined therapies including progesterone. NIH/PMC — Pivazyan, 2023
✓ Potential sleep benefits — Progesterone metabolism produces neuroactive steroids with GABA-modulating effects, possibly supporting sleep. NIH/PubMed — Gasser, 2021
✓ Bone health potential — Progesterone may interact with osteoblast activity; some evidence supports bone support in postmenopausal women. NIH/PMC — Tufts Univ Review
✓ Inflammation modulation — Progesterone shows anti-inflammatory properties in joint and connective tissues, though mostly preliminary studies. NIH/PubMed — Irwin, 2013
✓ Mood support potential — Progesterone’s neurosteroid metabolites may have mood-stabilizing effects, but more clinical data are needed. NIH/PubMed — Gasser, 2021
University-Led & Academic Studies
✓ Medical University of Vienna — Double-blind, vehicle-controlled RCT: 2% topical progesterone increased skin elasticity/firmness and reduced wrinkle counts vs. control in peri-/postmenopausal women. NIH/PubMed — Holzer, 2005
✓ USC Keck School of Medicine — Randomized cross-over study: after topical progesterone, capillary blood and saliva levels were ~100× and ~10× higher than serum, indicating robust tissue uptake; serum alone underestimates exposure. NIH/PubMed — Du, 2013
✓ University of Southern California — Clinical analysis: despite low serum levels with creams, antiproliferative effects on endometrium have been observed in studies of transdermal progesterone. NIH/PubMed — Stanczyk, 2005
✓ University of Bradford (Centre for Skin Sciences) — Review: sex hormones (incl. progesterone) influence dermal collagen/elastic fibers; hormonal therapy can improve elasticity, thickness, and wrinkle metrics in estrogen-deficient skin. NIH/PMC — Thornton, 2013
✓ Baker Medical Research Institute (Melbourne) — Double-blind cross-over RCT of topical wild yam extract (a diosgenin source) showed no meaningful hormonal/symptom changes vs. placebo, underscoring that bio-identical USP progesterone (not raw yam) is required for effect. NIH/PubMed — Komesaroff, 2001
We monitor research from leading institutions — Harvard, Johns Hopkins, Mayo Clinic, Cleveland Clinic, Cambridge, Oxford, Stanford, Yale, MIT, the University of Florida, Oregon State University – Linus Pauling Institute, Tufts, Boston University, Cornell, Columbia, Ohio State — to align with credible science.*
Key Ingredients
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USP Progesterone (20 mg per pump) — Bio-identical progesterone identical in molecular structure to the hormone produced naturally (NIH/PubMed — Holzer, 2005).
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Wild Yam Extract — Source of diosgenin, used in lab conversion to natural progesterone. Well-tolerated in clinical testing (NIH/PubMed — Komesaroff, 2001).
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Balancing Botanical Blend — Includes herbs and natural oils for skin nourishment and absorption support.*
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Natural Cream Base — Gentle emollient formula designed for optimal transdermal delivery, free from parabens and artificial fragrances.*
Brief Benefit Bullets
- Improves skin elasticity and firmness*
- Reduces wrinkle count and depth*
- Supports bio-identical hormonal balance*
- Promotes collagen and hydration*
- Transdermal absorption with measurable systemic levels*
- Safer profile compared to synthetic progestins*
- Formulated with complementary Botanicals*
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3rd-party lab tested for purity & potency
Suggested Use
Dispense 1 full pump (≈1.3 g cream, ≈20 mg USP progesterone) and massage into inner arms, thighs, chest, or abdomen. Rotate sites daily. Use days 12–26 of cycle for premenopausal women; for postmenopausal, apply for 21 days, discontinue for 7 days, and repeat. For external use only. Do not use if pregnant or nursing.*
Product Specifications
• Serving Size — 1 pump (1.3 g cream ≈ 20 mg progesterone)
• Servings Per Container — ≈65 pumps
• Form — Topical cream
• Free From — Artificial colors, parabens, synthetic fragrances*
• Quality — Third-party tested for identity, potency & purity
LifeSource Vitamins — Proudly American — Since 1992
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Progesterone Balancing Skin Cream — 20 mg USP bio-identical, supports skin elasticity, wrinkle reduction & women’s hormonal wellness. 3rd-party tested. Clinically Studied Ingredients — NIH/PubMed!*
