SAM-e 200 mg - 30 Tablets
SAM-e 200 mg - 30 Tablets
SAM-e 200 mg - 30 Tablets
SAM-e 200 mg - 30 Tablets
SAM-e 200 mg - 30 Tablets
SAM-e 200 mg - 30 Tablets
SAM-e 200 mg - 30 Tablets
LifeSource Vitamins
Rated 4.5 out of 5
2 Reviews

SAM-e 200 mg - 30 Tablets

Original Price: $29.99   Current Price: $29.99
  • Supports emotional balance and mood*
  • Supports joint comfort and mobility*
  • Supports natural inflammatory response*
  • Supports cognitive function and clarity*
  • Supports natural detoxification processes*
  • Supports daily energy and vitality*
  • Enteric-coated 200 mg SAM-e*
  • Third-Party Tested for Purity & Quality*
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Product Details

LifeSource Vitamins SAM-e 200 mg — Enteric-Coated Tablets, 60 Count — Supports Mood & Joint Health*

Clinically studied S-adenosyl-L-methionine (SAM-e) to support mood, joint comfort, and liver health. Enteric-coated for stability and absorption. Produced in FDA-registered, GMP-certified facilities and 3rd-party tested for identity, potency & purity.*

Research-Driven & Verified Product.
Explore the clinical research, ingredient science, and global evidence supporting this product below.
Research Promise: At LifeSource Vitamins, our commitment is rooted in research and results. Every benefit below is supported by human clinical studies indexed in the National Institutes of Health (NIH) via PubMed, with full texts available in the National Library of Medicine (NLM) PubMed Central (PMC) when available. In addition, we reference reviews from 39 leading health organizations and insights from 20 top global universities to ensure our guidance aligns with credible science.*
Clinically Studied Benefits

✓ Improves depressive symptoms (vs. placebo) — Inpatients with major depressive disorder taking oral SAM-e showed significant symptom improvement vs. placebo (randomized, double-blind). NIH/PubMed — Kagan, 1990

✓ Comparable to a prescription TCA with better tolerability — In two multicenter randomized double-blind trials, SAM-e matched imipramine’s antidepressant efficacy with fewer adverse events. NIH/PubMed — Delle Chiaie, 2002

✓ Reduces knee osteoarthritis pain & improves function — Randomized double-blind trial (IV then oral SAM-e) showed clinically meaningful pain reduction vs. placebo in knee OA. NIH/PubMed — Bradley, 1994

✓ Improves pruritus in intrahepatic cholestasis of pregnancy — Randomized study found pruritus improvement with SAM-e; UDCA and combination therapy improved biochemistries more. NIH/PubMed — Binder, 2006

Additional / Promising Evidence

✓ Depression (evidence synthesis) — Systematic reviews/meta-analyses of RCTs report overall antidepressant effects of SAM-e vs. placebo or parity with SSRIs/TCAs; results vary and more large trials are needed. NIH/PubMed — Limveeraprajak, 2024

✓ Osteoarthritis (evidence synthesis) — Cochrane review summary: SAM-e may improve pain/function in hip/knee OA; effect sizes modest and heterogeneous. NIH/PMC — Rutjes, 2009

✓ Liver disease (mixed findings) — Reviews/meta-analyses show biochemical improvements in some cholestatic conditions; benefit vs. UDCA often smaller. NIH/PLOS ONE — Guo, 2015

University-Led & Academic Studies

✓ Massachusetts General Hospital / Harvard — Placebo-controlled trials comparing SAM-e with escitalopram/placebo in MDD. NIH/PMC — Mischoulon, 2014

✓ Multicenter European programs — Double-blind trials found SAM-e comparable to imipramine with fewer adverse events. NIH/PubMed — Delle Chiaie, 2002

We monitor research from leading institutions — Harvard, Johns Hopkins, Mayo Clinic, Cleveland Clinic, Cambridge, Oxford, Stanford, Yale, MIT, the University of Florida, Oregon State University – Linus Pauling Institute, Tufts, Boston University, Cornell, Columbia, Ohio State — to align with credible science.*
Key Ingredients
  • S-Adenosyl-L-Methionine (SAM-e) — Methyl donor studied in human trials for mood, joint, and cholestatic liver outcomes (NIH/PubMed — Kagan, 1990).
Brief Benefit Bullets
  • Supports a healthy, positive mood*
  • Helps maintain joint comfort in everyday activity*
  • Supports liver health in select settings*
  • 3rd-party lab tested for purity & potency
Suggested Use

Take 1 tablet daily on an empty stomach, or as directed by your healthcare professional. Do not exceed suggested use. If pregnant, nursing, taking medications, or have a medical condition (including bipolar disorder), consult your physician. Keep out of reach of children.*

Product Specifications

• Serving Size — 1 enteric-coated tablet

• Amount Per Serving — SAM-e 200 mg (from 400 mg s-adenosyl-L-methionine tosyolate)

• Servings Per Container — 60

• Form — Enteric-coated tablets

• Free From — Non-GMO, gluten-free, no artificial colors or preservatives*

• Quality — Third-party tested for identity, potency & purity

3rd-Party Testing: Every batch is independently verified for identity, potency, and purity.
Click here to see our 3rd-party testing.

LifeSource Vitamins — Proudly American — Since 1992

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

SAM-e 200 mg enteric-coated tablets — supports mood, joint comfort & liver health; third-party tested. Clinically Studied Ingredients — NIH/PubMed!*

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