LifeSource Vitamins St. John’s Wort — 300 mg Capsules — Mood & Emotional Balance*
LifeSource Vitamins St. John’s Wort offers a standardized Hypericum perforatum extract (300 mg, 0.3% hypericin) to support mood balance, emotional wellness, and mental resilience. Non-GMO, gluten-free, and produced in FDA-registered, GMP-certified facilities with independent quality verification.*
Research Promise: At LifeSource Vitamins, our commitment is rooted in research and results. Every benefit below is supported by human clinical studies indexed in the National Institutes of Health (NIH) via PubMed, with full texts available in the National Library of Medicine (NLM) PubMed Central (PMC) when available. In addition, we reference reviews from 39 leading health organizations and insights from 20 top global universities to ensure our guidance aligns with credible science.*
Clinically Studied Benefits (with research)
• Improves depressive symptoms vs. placebo — Evidence from meta-analyses shows SJW extracts outperform placebo in mild-to-moderate depression.
(PubMed Linde et al. 2008)
• Comparable to antidepressants — In many trials, SJW matched SSRIs/tricyclics in effect with fewer side effects.
(Cochrane CD000448 Review)
• Broad systematic review support — A 2016 umbrella review confirms SJW monotherapy is superior to placebo and not inferior to antidepressants in mild to moderate depression.
(Apaydin et al. 2016)
• Safe tolerability profile — Users often report fewer adverse events and lower dropout rates compared to conventional antidepressants.
(Cochrane Review Safety Section)
• Mayo Clinic overview of interactions & use — Highlights both beneficial effects for mood and potential drug interactions.
(Mayo Clinic)
• Mechanism via hyperforin/TRPC6 — Hyperforin modulates sodium/calcium channels and neurotransmitter uptake through TRPC6 activation.
(Nature study, 2022)
• Pharmacodynamics & enzyme modulation — Clinical and bench research notes enzyme induction effects, relevant to drug interactions.
(NCBI Bookshelf on Hypericum perforatum)
• Systematic safety reviews — Integrated reviews support low incidence of major side effects in monitored use.
(Cochrane safety data)
• Clinical guideline acknowledgment — Many therapeutic guidelines reference SJW as optional in mild–moderate depression.
(American Family Physician review)
• Long-term review caution — Effects vary, and severe depression evidence is limited.
(RAND systematic review)
Additional Studies Showing Promising Benefits*
• Adjunctive use in therapy* — Some trials explore SJW use with conventional antidepressants, with mixed safety/efficacy signals.
(ClinicalTrials.gov NCT00005013)
• Photosensitivity risk* — Hypericin may increase sensitivity to sunlight, especially in high doses or interaction contexts.
(Mayo Clinic cautions)
• Drug interaction risk* — Enzyme induction (CYP450, P-gp) and transporter modulation are well documented clinically.
(NCBI Book on H. perforatum)
• Mixed evidence in minor depression* — Some clinical trials fail to separate SJW from placebo in milder cases.
(Minor depression RCT)
• Comparative safety in meta-analyses* — Pooled data show fewer side effects and less dropout vs. antidepressants.
(Apaydin et al. 2016 meta review)
• Mechanistic insight* — Recent preclinical studies on hyperforin and TRPC6 deepen understanding of action.
(Nature TRPC6/hyperforin)
Global Evidence & Authoritative Reviews
• World Health Organization & mental health treatment guidelines — botanical therapies including SJW are sometimes referenced for mild–moderate depressive symptoms (as adjunctive or alternative).
• Pharmacognosy and herbal compendia provide safety warnings regarding drug interactions, photosensitivity, and standardized extract variability.
We monitor research from the world’s leading institutions for all of the next products going forward — including Harvard, Johns Hopkins, Mayo Clinic, Cleveland Clinic, Cambridge University, Oxford, Stanford, Yale, MIT, the University of Florida, Oregon State University – Linus Pauling Institute, Tufts, Boston University, Cornell, Columbia, and Ohio State — to ensure our guidance remains aligned with the highest standards of credible science.*
Brief Benefit Bullets
• Supports mood & depressive symptom relief*
• Comparable efficacy to antidepressants in mild/moderate depression*
• Lower adverse events and dropout risk*
• Non-GMO, gluten-free, vegan capsules*
• Standardized Hypericum extract, 0.3% hypericin
• 3rd-party lab tested for purity & potency
Suggested Use: Take one (1) capsule up to three (3) times daily, preferably with meals or as directed by a healthcare professional. Use caution: St. John’s Wort is known to interact with many medications (including SSRIs, anticoagulants, oral contraceptives, HIV drugs, transplant drugs). Avoid prolonged sun exposure due to photosensitivity. Consult your physician before use, especially if on any medications or managing chronic conditions.*
Product Specifications
• Serving Size — 1 capsule (Hypericum perforatum extract, 300 mg, 0.3% hypericin)
• Servings Per Container — 100
• Form — Capsule (vegetarian cellulose)
• Free From — Non-GMO, gluten-free; vegan*
• Quality — Third-party tested for identity, potency & purity
Key Ingredients
St. John’s Wort (Hypericum perforatum) extract, 300 mg — standardized to 0.3% hypericin to support mood balance and emotional wellness.*
(PubMed Linde et al. 2008)
Hyperforin / Hypericin — active compounds associated with neurotransmitter modulation and known drug-interaction risk pathways.*
(Nature TRPC6/hyperforin 2022)
LifeSource Vitamins — Proudly American — Since 1992
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
St. John’s Wort 300 mg — standardized Hypericum extract for mild-to-moderate mood support.* Clinically Studied Ingredients — NIH/PubMed!*
