LifeSource Vitamins St. John’s Wort — 300 mg, Capsules, 90 — Mood Support*
LifeSource Vitamins St. John’s Wort provides a standardized Hypericum perforatum extract plus organic flowering herb to support mood balance, emotional wellness, and overall resilience. Non-GMO, vegan, gluten-free, and produced in FDA-registered, GMP-certified facilities with independent 3rd-party testing for quality assurance.*
Research Promise: At LifeSource Vitamins, our commitment is rooted in research and results. Every benefit below is supported by human clinical studies indexed in the National Institutes of Health (NIH) via PubMed, with full texts available in the National Library of Medicine (NLM) PubMed Central (PMC) when available. In addition, we reference reviews from 39 leading health organizations and insights from 20 top global universities to ensure our guidance aligns with credible science.*
Clinically Studied Benefits (with research)
• Improves depressive symptoms — Meta-analyses show St. John’s Wort extracts outperform placebo in mild-to-moderate depression.
(NIH/PubMed — Linde K, 2008)
• Comparable to antidepressants — SJW performed as well as SSRIs and tricyclics in many trials with fewer side effects.
(Cochrane — St. John’s Wort Review, 2017)
• Systematic review support — An umbrella review confirmed SJW is more effective than placebo and not inferior to antidepressants.
(NIH/PMC — Apaydin EA, 2016)
• Safe tolerability profile — Lower adverse event rates than conventional antidepressants.
(Cochrane — Safety Data)
• Mayo Clinic evidence summary — Confirms benefits and cautions about drug interactions.
(Mayo Clinic — St. John’s Wort Overview)
• Mechanism of action — Hyperforin modulates neurotransmitter reuptake through TRPC6 ion channels.
(Nature — Müller WE, 2022)
• Drug interaction data — Documented induction of CYP450 and P-gp pathways.
(NCBI Bookshelf — Hypericum Monograph)
• Systematic safety review — Confirms relatively safe profile when monitored clinically.
(Cochrane — Safety)
• Clinical guideline acknowledgement — Recognized as an option for mild-to-moderate depression.
(AAFP — Diagnosis & Treatment of Depression)
• Limitations — Evidence weak in severe depression; quality varies by extract.
(RAND — Systematic Review)
Additional Studies Showing Promising Benefits*
• Adjunctive therapy — Investigated in combination with antidepressants.
(ClinicalTrials.gov — NCT00005013)
• Photosensitivity risk — High doses linked to light sensitivity.
(Mayo Clinic — Safety Notes)
• Drug interaction caution — CYP3A4 & transporter induction well documented.
(NCBI Bookshelf — Hypericum)
• Variable response in mild depression — Some RCTs show no difference from placebo.
(NIH/PubMed — Shelton RC, 2002)
• Comparative safety in meta-analyses — Lower discontinuation rates than SSRIs.
(NIH/PMC — Apaydin EA, 2016)
• Mechanistic insights — Hyperforin and TRPC6 activity studied extensively.
(Nature — Müller WE, 2022)
Global Evidence & Authoritative Reviews
• NCCIH — Reviews St. John’s Wort for depression and cautions about drug interactions.
(NCCIH — 2023)
• WHO (World Health Organization) — Traditional medicine recognition for Hypericum perforatum use.
(WHO — Monographs on Selected Medicinal Plants)
• EMA (European Medicines Agency) — Herbal monograph on Hypericum perforatum for mild depressive episodes.
(EMA — HMPC Monograph)
We monitor research from the world’s leading institutions for all of the next products going forward — including Harvard, Johns Hopkins, Mayo Clinic, Cleveland Clinic, Cambridge University, Oxford, Stanford, Yale, MIT, the University of Florida, Oregon State University – Linus Pauling Institute, Tufts, Boston University, Cornell, Columbia, and Ohio State — to ensure our guidance remains aligned with the highest standards of credible science.*
Brief Benefit Bullets
• Standardized Hypericum extract for mood support*
• Backed by NIH/PubMed clinical studies*
• May improve mild-to-moderate depressive symptoms*
• Fewer adverse events vs. antidepressants*
• Non-GMO, vegan, gluten-free capsules*
• 3rd-party tested for purity & potency
Suggested Use: Take one (1) capsule daily, preferably with meals, or as directed by your healthcare professional. Do not exceed recommended dose. Consult your physician if taking medications (SSRIs, anticoagulants, contraceptives, transplant/HIV drugs). Limit sun exposure due to possible photosensitivity.*
Product Specifications
• Serving Size — 1 Veggie Capsule
• Servings Per Container — 90
• Actives — St. John’s Wort Herb 300 mg (0.3% Hypericin) + St. John’s Wort Flowering Herb (Organic, Hypericum perforatum) 150 mg
• Form — Vegetarian capsule (cellulose)
• Free From — Non-GMO, gluten-free, vegan*
• Quality — Third-party tested for identity, potency & purity
Key Ingredients
St. John’s Wort Herb Extract — 300 mg (0.3% Hypericin) — standardized for active hypericin to support mood balance.*
(NIH/PubMed — Linde K, 2008)
Organic St. John’s Wort Flowering Herb — 150 mg — supports synergy with standardized extract for emotional wellness.*
(NIH/PMC — Apaydin EA, 2016)
LifeSource Vitamins — Proudly American — Since 1992
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
St. John’s Wort 300 mg, 90 Capsules — standardized Hypericum extract plus organic herb for emotional balance.* Clinically Studied Ingredients — NIH/PubMed!*
