Superior Methyl-B Complex --- Methylated B-Vitamins, Vegan Capsules, 120 --- Supports Energy Metabolism & Brain Health 12 Synergistic Ingredients*
Lifesource Vitamins Superior Methyl-B Complex delivers bioactive, methylated B-vitamins (B-1, B-2, B-3, B-5, P-5-P (B-6), methylcobalamin (B-12), 5-MTHF folate, biotin) with choline, inositol, PABA, CoQ10, and alpha-lipoic acid to support cellular energy metabolism, brain and nervous-system health, red blood cell formation, and homocysteine metabolism. Produced in FDA-registered, GMP-certified facilities and 3rd-party lab tested for identity, potency & purity.*
Research Promise: At Lifesource Vitamins, our commitment is rooted in research and results. Every benefit below is supported by human clinical studies indexed in the National Institutes of Health (NIH) via PubMed, with full texts available in the National Library of Medicine (NLM) PubMed Central (PMC) when available. In addition, we reference reviews from 39 leading health organizations and insights from 20 top global universities to ensure our guidance aligns with credible science.*
Clinically Studied Benefits (with research)
- Corrects B-12 deficiency (hematologic & neurologic) — High-dose oral B-12 (1,000–2,000 mcg/day) is as effective as intramuscular injections in randomized trials for deficiency, normalizing biomarkers and supporting clinical outcomes. (Vidal-Alaball 2005, PubMed; Cochrane 2018, PMC)
- Neuropathy & nerve function (B-12) — Oral methylcobalamin 1 mg/day improved neurophysiology, sudomotor function, pain, and quality of life vs placebo over 12 months (double-blind RCT). (Didangelos 2021, PMC)
- Homocysteine & brain atrophy (MCI subgroup) — In older adults with mild cognitive impairment and elevated homocysteine, folic acid+B-6+B-12 slowed whole-brain atrophy on MRI vs placebo (DB-RCT). (Smith 2010, PLoS One, PMC)
- Cognition in folate-insufficient elders — Three-year folic acid supplementation improved memory and processing speed vs placebo in older adults with low baseline folate (DB-RCT). (Durga 2005, Lancet, PubMed)
- Stress & mood in healthy but stressed adults — B-complex formulations reduced perceived stress and improved mood/well-being in randomized, placebo-controlled trials. (Stough 2014, PMC; Kennedy 2010, PubMed)
- Adjunctive methylfolate for mood (select adults) — L-methylfolate (15 mg/day) improved depressive symptoms when added to SSRI therapy in SSRI-resistant major depression (DB-RCTs). (Papakostas 2012, PubMed; Papakostas 2014, PubMed)
Promising/Traditional (with human data & limitations)*
- Homocysteine & cardiovascular outcomes* — Although B-vitamins (including folate, B-6, B-12) lower homocysteine, large outcome RCTs did not reduce major cardiovascular events. (HOPE-2, NEJM 2006)
- Alpha-lipoic acid & neuropathic symptoms* — Human trials (oral and IV) suggest symptom improvements in diabetic neuropathy; effect sizes vary by dose/route (evidence mixed; more oral RCTs needed). (Ziegler 2004, PubMed)
- CoQ10 & fatigue/energy* — Some RCTs report modest improvements in fatigue or exercise capacity in select groups; findings are heterogeneous. (Littarru 2012, PubMed)
University & Global Studies (Human — PubMed/PMC-Linked)
We monitor research from the world’s leading institutions — including Harvard, Johns Hopkins, Mayo Clinic, Cleveland Clinic, Cambridge University, Oxford, Stanford, Yale, MIT, the University of Florida, Oregon State University – Linus Pauling Institute, Tufts, Boston University, Cornell, Columbia, and Ohio State — to ensure our guidance remains aligned with the highest standards of credible science.*
Brief Benefit Bullets
- Supports cellular energy metabolism (coenzyme roles of B-vitamins)*
- Helps maintain healthy homocysteine metabolism*
- Supports neurologic function & myelin with adequate B-12 status*
- May support mood and stress in select groups (human RCTs)*
- 3rd-party lab tested for purity & potency
Suggested Use
Take 2 capsules daily with a meal, or as directed by your healthcare professional. Do not exceed recommended dose. If pregnant, nursing, taking medications, or have a medical condition, consult your physician.*
Product Specifications
- Serving Size — 2 Capsules
- Servings Per Container — 60
- Form — Vegan Capsules
- Free From — No artificial colors, flavors, or preservatives; no wheat, gluten, milk, eggs, peanuts, tree nuts, soy, crustacean shellfish, or fish; vegan*
- Quality — Third-party tested for identity, potency & purity
Perfect For:
- Adults seeking daily methylated B-vitamin support for energy & cognition*
- Individuals with dietary limitations or genetic variants (e.g., MTHFR) affecting folate metabolism*
- Those aiming to support homocysteine metabolism and neurologic function*
Key Ingredients
Methylcobalamin (Vitamin B-12) — Essential for neurologic function and red blood cell production; high-dose oral therapy effective for deficiency in RCTs. (Vidal-Alaball 2005; Cochrane 2018)
5-MTHF Folate — Bioactive folate supporting one-carbon metabolism and homocysteine reduction; adjunctive benefit in SSRI-resistant depression shown with L-methylfolate. (Papakostas 2012)
Pyridoxal-5′-phosphate (B-6) — Active coenzyme form involved in neurotransmitter synthesis; part of effective B-complex formulations in stress/mood RCTs. (Stough 2014)
CoQ10 & Alpha-lipoic acid — Mitochondrial/redox cofactors with human data suggesting benefits in select populations (evidence heterogeneous; see Promising section).
Lifesource Vitamins — Proudly American — Since 1992
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Superior Methyl-B Complex — daily methylated B-vitamin support for energy, brain & homocysteine metabolism. Human studies (PubMed/PMC) + 3rd-party tested!*
