UC-II® 40 mg — 60 Capsules — Joint Support with Aquamin — Advanced Joint Health & Mobility Support*
LifeSource Vitamins UC-II Joint Support pairs clinically researched undenatured type II collagen with Aquamin® marine multimineral complex to support joint comfort, flexibility, and healthy mobility.* Produced in FDA-registered, GMP-certified facilities and 3rd-party lab tested for purity, potency, and label accuracy.
Research Promise: At LifeSource Vitamins, our commitment is rooted in research and results. Every benefit below is supported by human clinical studies indexed in the National Institutes of Health (NIH) via PubMed, with full texts in the National Library of Medicine (NLM) PubMed Central (PMC) when available. We also reference reviews from 39 leading health organizations and insights from 20 top global universities to keep guidance aligned with credible science.*
Clinically Studied Benefits (with research)
- Improved knee joint extension — Daily UC-II (40 mg) improved knee extension in active adults with activity-related joint discomfort (12 wks). NIH/PubMed — Lugo JP, 2013
- Enhanced knee ROM & function — UC-II improved flexion/extension range and functional measures over 24 wks in active adults. NIH/PubMed — Bloch MH, 2022
- Reduced joint pain vs placebo — Significant improvements in pain during walking/standing and at rest in controlled trials. NIH/PubMed — Gupta RC, 2016
- Osteoarthritis symptom relief — UC-II outperformed glucosamine + chondroitin for total WOMAC in knee OA. NIH/PubMed — Liu X, 2016
- Oral-tolerance mechanism — UC-II supports antigen-specific oral tolerance and T-regulatory pathways relevant to joint comfort. NIH/PubMed — D’Amelio P, 2020
- Aquamin functional support — Marine multimineral complex improved 6-min walk distance and function (12 wks) in knee OA. NIH/PubMed — Frestedt JL, 2008
- NSAID-sparing pilot — Aquamin enabled partial NSAID withdrawal while maintaining function. NIH/PubMed — Jensen GS, 2009
- Mineral bioavailability — Marine-derived Ca/Mg complexes show favorable bioavailability. NIH/PubMed — Kaur P, 2018
Additional Potential Benefits*
University / Academic Context*
• Oral-tolerance mechanism* — UC-II supports antigen-specific T-regulatory pathways relevant to joint comfort.
(NIH/PubMed — D’Amelio P, 2020)
• Active adults: ROM & function* — UC-II improved knee flexion/extension range and functional measures (24 weeks).
(NIH/PubMed — Bloch MH, 2022)
• Athletes: exertion & discomfort* — 40 mg/day UC-II reduced activity-related joint pain and lengthened pain-free exertion time (12 weeks).
(NIH/PubMed — Lugo JP, 2013)
• OA symptom context* — UC-II outperformed glucosamine + chondroitin on total WOMAC in knee OA.
(NIH/PubMed — Liu X, 2016)
• Marine minerals: bioavailability* — Red-algae Ca/Mg complexes show favorable bioavailability (Aquamin context).
(NIH/PubMed — Kaur P, 2018)
Global Evidence & Authoritative Reviews*
• UC-II across OA populations* — Clinical outcomes and safety summarized.
(NIH/PubMed — Gupta RC, 2016) (NIH-indexed reviews)
• Updated UC-II clinical context* — Mechanisms and human evidence overview.
(NIH/PubMed — Bansal S, 2023) (NIH-indexed reviews)
• Collagen peptides in knee OA* — Meta-analysis shows symptom improvement vs placebo.
(NIH/PubMed — Lin CR, 2023) (NIH-indexed reviews)
• Collagen + activity / recovery* — Systematic review in athletes for joint function and recovery.
(NIH/PubMed — Zdzieblik D, 2021) (NIH-indexed reviews)
• Marine multiminerals overview* — Evidence on absorption and functional support for skeletal health.
(NIH/PubMed — Kaur P, 2018) (NIH-indexed reviews)
We monitor research from leading institutions — Harvard University, Johns Hopkins University, Mayo Clinic, Cleveland Clinic, Cambridge University, Oxford University, Stanford University, Yale University, Tufts University, University of Florida, Oregon State University – Linus Pauling Institute, Columbia University, Cornell University, and more — to keep our guidance aligned with credible science.*
Brief Benefit Bullets
- Supports joint comfort, flexibility & healthy range of motion*
- Clinically researched UC-II® 40 mg once daily*
- Aquamin® marine minerals for joint & bone co-support*
- Backed by human trials in active adults and OA populations*
- Non-GMO; produced in FDA-registered, GMP-certified facilities*
- 3rd-party lab tested for purity & potency*
Key Ingredients
UC-II® (Undenatured Type II Collagen, 40 mg) — Native collagen from chicken sternum cartilage that preserves its triple-helix structure, supporting antigen-specific oral tolerance pathways tied to joint comfort.*
Aquamin® (250 mg; providing Calcium 80 mg, 6% DV) — Marine multimineral complex from red algae delivering bioavailable calcium, magnesium, and trace minerals for musculoskeletal co-support.*
Suggested Use
Adults: Take 1 capsule daily (preferably at bedtime and/or on an empty stomach), or as directed by your healthcare professional. If pregnant, nursing, taking medications, or have a medical condition, consult your physician. Do not exceed suggested use.*
Product Specifications
- Serving Size — 1 capsule
- Servings Per Container — 60 (60 capsules)
- Actives (per capsule) — UC-II® Standardized Chicken Cartilage 40 mg; Aquamin® (whole plant) 250 mg providing Calcium 80 mg (6% DV)
- Other Ingredients — Hypromellose (cellulose) capsule, microcrystalline cellulose, non-GMO corn starch, potassium chloride (stabilizer), stearic acid (vegetable source), silicon dioxide
- Form — Vegetarian capsules; Non-GMO
- Quality — Third-party tested for identity, potency & purity
Perfect For:
- Active individuals seeking support for exercise-related joint discomfort*
- Adults wanting once-daily joint support for comfort and mobility*
- Those looking to complement bone/joint nutrition with marine minerals*
3rd Party Testing
Every batch is independently verified for identity, potency, and purity. Click here to view our 3rd-party testing.
LifeSource Vitamins — Proudly American — Since 1992
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
UC-II® 40 mg with Aquamin — 60 capsules — supports joint comfort, flexibility & mobility; once-daily, 3rd-party tested. Clinically Studied Ingredients — NIH/PubMed!*
