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Lifesource Vitamins Vein Health — 90 Vegetarian Capsules — Diosmin & Hesperidin for Healthy Veins & Circulation*
Lifesource Vitamins Vein Health provides a clinically studied blend of citrus bioflavonoids — diosmin and hesperidin — to support venous tone, leg comfort, and circulatory wellness. Produced in FDA-registered, GMP-certified facilities and 3rd-party tested for identity, potency & purity.*
Research Promise: At Lifesource Vitamins, our commitment is rooted in research and results. Every benefit below is supported by human clinical studies indexed in the National Institutes of Health (NIH) via PubMed, with full texts available in the National Library of Medicine (NLM) PubMed Central (PMC) when available. In addition, we reference reviews from 39 leading health organizations and insights from 20 top global universities to ensure our guidance aligns with credible science.*
Clinically Studied Benefits (with research)
• Supports CVI symptoms (leg pain, heaviness, swelling) — Micronized purified flavonoid fraction (MPFF; diosmin+hesperidin) improved multiple venous symptoms vs placebo in randomized trials and systematic review.
(NIH/PubMed — Kakkos S, 2018)
• Improves venous microcirculation & edema — Clinical data showed reduced edema and improved microcirculatory parameters with MPFF.
(NIH/PubMed — Nicolaides A, 2003)
• Enhances quality of life & leg function — Randomized, double-blind studies reported symptom score reductions and better functional outcomes in CVD.
(NIH/PubMed — Struckmann J, 1999)
• Reduces lower-limb volume/pain — Network meta-analysis found MPFF among the most effective options for leg volume and pain scales.
(NIH/PubMed — Pompilio G, 2021)
• Supports venous ulcer healing (adjunctive) — Meta-analysis showed accelerated healing when MPFF was added to standard care.
(NIH/PubMed — Coleridge-Smith P, 2005)
• Relieves hemorrhoid-related symptoms — RCTs and reviews reported reduced bleeding, pain, and recurrence with diosmin/hesperidin-based therapy.
(NIH/PubMed — Ho YH, 1995)(NIH/PubMed — Giannini I, 2015)(NIH/PMC — Sheikh P, 2020)
• Effective across trials & real-world practice — Evidence syntheses and clinical data support MPFF benefits in typical care settings.
(NIH/PMC — Lurie F, 2023)(NIH/PubMed — Ulloa J, 2023)
• Low-dose diosmin RCT evidence — Randomized, double-blind trial found improved symptoms and quality of life in chronic venous disease with low-dose diosmin.
(NIH/PMC — Serra R, 2021)
Additional Studies Showing Promising Benefits*
• Dose scheduling & adherence — Once-daily 1000 mg vs 500 mg twice-daily MPFF showed comparable efficacy with adherence advantages (symptomatic CVD).
(NIH/PubMed — Cui HJ, 2024)
• Updated clinical perspective — Reviews summarize mechanistic and clinical signals for MPFF in pain, swelling, cramps, and functional discomfort.
(NIH/PMC — Ulloa J, 2019)(NIH/PMC — Bouskela E, 2022)
University Studies
• University-centered trials and analyses reported symptom reductions and QoL gains with MPFF in chronic venous disease.
(NIH/PubMed — Kakkos S, 2018)(NIH/PubMed — Nicolaides A, 2003)
Global Evidence & Authoritative Reviews
• Office of Dietary Supplements (NIH) — Flavonoids and vascular support context (evidence overviews).
(ODS — NIH)
• National Center for Complementary and Integrative Health — Evidence & safety perspectives relevant to bioflavonoids and integrative vascular support.
(NCCIH — NIH)
• U.S. Pharmacopeia — Quality standards guidance for dietary supplements.
(USP — Ongoing)
We monitor research from the world’s leading institutions — including Harvard, Johns Hopkins, Mayo Clinic, Cleveland Clinic, Cambridge University, Oxford, Stanford, Yale, MIT, the University of Florida, Oregon State University – Linus Pauling Institute, Tufts, Boston University, Cornell, Columbia, and Ohio State — to ensure our guidance remains aligned with the highest standards of credible science.*
Brief Benefit Bullets
• Supports healthy vein tone & leg comfort*
• Helps reduce occasional swelling and heaviness in the legs*
• Promotes microcirculatory strength and capillary integrity*
• Clinically studied blend: diosmin + hesperidin*
• Backed by randomized trials, meta-analyses & real-world data*
• Gentle and well-tolerated when used as directed*
• 3rd-party lab tested for purity & potency
Suggested Use: See product label for full instructions, or as directed by your healthcare professional. Do not exceed recommended dose. If pregnant, nursing, taking medications, or have a medical condition, consult your physician.*
Product Specifications
• Serving Size — See Supplement Facts label
• Servings Per Container — See Supplement Facts label
• Form — Easy-to-swallow vegetarian capsules
• Free From — Non-GMO, gluten-free; no artificial colors or preservatives*
• Quality — Third-party tested for identity, potency & purity
Perfect For
• Adults seeking everyday vein & circulation support*
• Individuals experiencing occasional leg heaviness or swelling*
• Complementing lifestyle measures like movement and compression*
Key Ingredients
Diosmin & Hesperidin (MPFF) — venoactive citrus bioflavonoids that support venous tone, leg comfort, and microcirculation in clinical research.*
(NIH/PubMed — Kakkos S, 2018)(NIH/PubMed — Nicolaides A, 2003)
LifeSource Vitamins — Proudly American — Since 1992
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Diosmin + Hesperidin for healthy veins, leg comfort & microcirculation — backed by RCTs & reviews. Clinically Studied Ingredients — NIH/PubMed!*
