Vitamin D-3 125 mcg (5,000 IU) — 120 Softgels — Bone, Muscle & Immune Support*
High-potency Vitamin D3 (cholecalciferol) to support calcium absorption, strong bones & muscles, and healthy immune function.* Delivers 5,000 IU per softgel — an efficient option for adults working with a clinician to correct or maintain vitamin D status.* Produced in FDA-registered, GMP-certified facilities and 3rd-party lab tested for identity, potency & purity.
Research Promise: At LifeSource Vitamins, our commitment is rooted in research and results. Every benefit below is supported by human clinical studies indexed in the National Institutes of Health (NIH) via PubMed, with full texts available in the National Library of Medicine (NLM) PubMed Central (PMC) when available. In addition, we reference reviews from 39 leading health organizations and insights from 20 top global universities to ensure our guidance aligns with credible science.*
Clinically Studied Benefits (with research)
• Supports bone mineralization & calcium absorption — Vitamin D3 increases intestinal calcium uptake; deficiency correction improves skeletal outcomes in at-risk adults. (PubMed — 2020; NIH/ODS)
• Helps reduce falls & supports muscle function (older adults) — Trials/meta-analyses report improved lower-extremity function and lower fall risk with adequate vitamin D status. (Cochrane — 2011)
• Immune support / respiratory benefits — Patient-level meta-analysis of RCTs: vitamin D supplementation reduced acute respiratory infection risk, with greatest benefit in those deficient and with regular (not bolus) dosing. (NIH/PMC — BMJ 2017)
• Parathyroid (PTH) regulation — Correcting low 25(OH)D lowers secondary hyperparathyroidism, supporting bone turnover balance. (PubMed — 2020)
• Cardiometabolic markers (adjunct) — Evidence suggests potential improvements in endothelial and inflammatory markers in some groups; results vary by baseline status. (PubMed — 2021; NCCIH)
• Mood (adjunct) — Meta-analytic and clinical data indicate vitamin D may help mood regulation in deficiency; heterogeneity exists across trials. (PubMed — 2020; OSU LPI)
• Cancer outcomes (adjunct) — Large RCTs show no reduction in overall cancer incidence, but pooled analyses suggest possible lower cancer mortality with supplementation. (NEJM — 2018; Boston Univ. — 2023)
• Bone health across the lifespan — Adequate vitamin D prevents rickets/osteomalacia and supports peak bone mass accrual when combined with adequate calcium/protein. (PubMed — 2021; JAMA — 2022)
Additional Studies Showing Promising Benefits*
• Autoimmune modulation — Observational and interventional evidence suggests vitamin D sufficiency may be associated with lower autoimmune disease activity; confirmatory RCTs ongoing. (Frontiers Immunol. — 2019)
• Blood pressure — Some meta-analyses report modest BP effects in hypertensive/deficient adults; findings are mixed overall. (PubMed — 2021)
• Glycemic control / diabetes risk — Large RCTs show neutral primary outcomes overall, with exploratory benefits in participants with low baseline 25(OH)D. (NEJM — 2019)
• Joint & inflammatory symptoms — Mixed evidence for symptom improvement via immunomodulation; benefits may depend on deficiency correction. (PubMed — 2022)
• Colorectal adenoma (risk markers) — Some trials report favorable effects when combined with calcium; results vary by population. (AJCN — 2014)
• Cognition & fatigue (adjunct) — Signals for cognitive and vitality benefits in deficient adults require further high-quality RCTs. (PubMed — 2022; PubMed — 2022)
We monitor research from the world’s leading institutions — including Harvard, Johns Hopkins, Mayo Clinic, Cleveland Clinic, Cambridge University, Oxford, Stanford, Yale, MIT, OSU Linus Pauling Institute, Tufts, Boston University, Cornell, Columbia, and Ohio State — to ensure our guidance remains aligned with the highest standards of credible science.*
Brief Benefit Bullets
• Supports calcium absorption & bone mineralization*
• Helps maintain muscle strength; supports fall-risk reduction in older adults*
• Clinically shown to support immune defenses (especially if deficient)*
• Adjunct support for cardiometabolic and mood markers in select groups*
• 3rd-party lab tested for purity & potency
Suggested Use: Take 1 softgel every 2–3 days with a meal, or as directed by your healthcare professional.* Individuals targeting specific blood levels (25(OH)D) should test and personalize dosing with their clinician. Do not exceed recommended intake.
Product Specifications
• Serving Size — 1 softgel
• Vitamin D3 (cholecalciferol) — 125 mcg (5,000 IU) per softgel
• Servings Per Container — 120
• Form — Softgels
• Free From — Non-GMO, gluten-free, no artificial colors*
• Quality — Third-party tested for identity, potency & purity
Perfect For
• Adults with limited sun exposure or documented low 25(OH)D*
• Those seeking bone & muscle support, especially mid-life & older adults*
• Individuals working with a clinician on higher-potency repletion plans*
Key Ingredients
Vitamin D3 (Cholecalciferol) — the bioidentical form made in human skin, supports calcium absorption, bone/muscle function, and immune health.* (NIH/PMC — BMJ 2017; NIH/ODS)
LifeSource Vitamins — Proudly American — Since 1992
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Vitamin D3 5,000 IU softgels for targeted repletion and maintenance of healthy vitamin D levels — supports bones, muscles & immune health. Clinically Studied — NIH/PubMed*
