Vitamin D-3 — 25 mcg (1,000 IU) — 180 Softgels — Supports Bone Strength, Immune Health & Muscle Function* Also Available in New Value Size 360 Count
LifeSource Vitamins Vitamin D3 delivers clinically studied cholecalciferol (D3) in easy-to-take softgels to support calcium absorption, bone & muscle health, and everyday immune resilience. Produced in FDA-registered, GMP-certified facilities and 3rd-party tested for identity, potency & purity.*
Research Promise: At LifeSource Vitamins, our commitment is rooted in research and results. Every benefit below is supported by human clinical studies indexed in the National Institutes of Health (NIH) via PubMed, with full texts available in the National Library of Medicine (NLM) PubMed Central (PMC) when available. In addition, we reference reviews from 39 leading health organizations and insights from 20 top global universities to ensure our guidance aligns with credible science.*
Clinically Studied Benefits (with research)
• Supports bone strength & mineralization — D3 (800 IU/day) + calcium reduced hip and non-vertebral fractures in older women in a landmark randomized trial. (NEJM — 1992)
• Enhances calcium absorption — Controlled human studies show D3 repletes 25(OH)D and improves fractional calcium absorption, a key mechanism for bone health. (Am J Clin Nutr — 2003)
• Helps prevent falls in older adults — Meta-analysis of RCTs found vitamin D (≈700–1,000 IU/day) reduced fall risk versus control. (JAMA — 2004)
• Immune support / respiratory infections — Individual-patient meta-analysis of 25 RCTs showed D supplementation reduced acute respiratory infections, with greatest effect when deficient and using daily/weekly dosing. (BMJ — 2017 (PMC5310969))
• Maintains healthy 25(OH)D status — Human trials demonstrate D3 is more effective than D2 at raising and sustaining serum 25(OH)D levels. (Am J Clin Nutr — 1998)
• Cancer outcomes (adjunct) — In a large primary-prevention RCT, D3 (2,000 IU/day) did not lower overall cancer incidence but showed a signal for reduced cancer mortality on longer follow-up. (NEJM — 2018)
• Secondary hyperparathyroidism — Supplementation lowers elevated PTH in deficiency, supporting calcium–bone homeostasis. (Am J Clin Nutr — 2001)
• Community fracture prevention (population) — Periodic oral D3 prevented fractures and reduced mortality in older adults in a large community RCT. (BMJ — 2003)
Additional Studies Showing Promising Benefits*
• Type 2 diabetes risk (mixed) — In adults with prediabetes, daily D3 did not significantly reduce progression overall; exploratory analyses suggested benefit in those with low baseline 25(OH)D and good adherence. (NEJM — 2019)
• Mood / depression (mixed) — Large RCT in mid-late life found no reduction in incident depression with D3 vs placebo (adequate baseline status common). (JAMA — 2020)
• Cardiovascular endpoints (mixed) — Primary-prevention trial found D3 did not reduce major cardiovascular events vs placebo. (NEJM — 2018)
University Studies (Promising — Human / Academic Research)
• Harvard/Partners (VITAL) — Large nationwide RCT on D3 for primary prevention: neutral for overall CVD/cancer incidence; signal for lower cancer mortality on extended follow-up. (NEJM — 2018)
• International respiratory consortium — Individual-patient meta-analysis across universities showed protection against ARIs, especially in deficient individuals with regular dosing. (BMJ — 2017 (PMC))
Global Evidence & Authoritative Reviews*
• NIH ODS Vitamin D Fact Sheet (Health Pros) — Evidence, dosing, and safety overview for clinicians. (NIH ODS)
• Harvard T.H. Chan School — Educational review on vitamin D and health (bones, immunity, chronic disease context). (Harvard)
• Johns Hopkins Medicine — Patient-level guidance on vitamin D and immunity. (Johns Hopkins)
We monitor research from the world’s leading institutions — including Harvard, Johns Hopkins, Mayo Clinic, Cleveland Clinic, Cambridge University, Oxford, Stanford, Yale, MIT, the University of Florida, Oregon State University – Linus Pauling Institute, Tufts, Boston University, Cornell, Columbia, and Ohio State — to ensure our guidance remains aligned with the highest standards of credible science.*
Brief Benefit Bullets
• Helps maintain strong bones & teeth via calcium absorption*
• Immune support; helps reduce ARI risk when deficient*
• Supports muscle function; helps lower fall risk in older adults*
• Helps maintain healthy vitamin D status (25[OH]D)*
• 3rd-party lab tested for purity & potency
Suggested Use: Take 1 softgel daily with a meal, or as directed by your healthcare professional. Do not exceed recommended dose. If pregnant, nursing, taking medications, or have a medical condition, consult your physician.*
Product Specifications
• Serving Size — 1 softgel
• Servings Per Container — 180
• Active — Vitamin D3 (Cholecalciferol) — 25 mcg (1,000 IU) per softgel
• Form — Softgels
• Free From — Non-GMO, gluten-free, no artificial colors*
• Quality — Third-party tested for identity, potency & purity
Perfect For
• Adults with limited sun exposure seeking bone & immune support*
• Older adults supporting muscle function and fall risk reduction*
• Anyone maintaining healthy vitamin D status year-round*
Key Ingredients
Vitamin D3 (Cholecalciferol) — supports calcium absorption, bone & muscle function, and immune health.* (NEJM — 1992; BMJ — 2017 (PMC))
LifeSource Vitamins — Proudly American — Since 1992
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
LifeSource Vitamins Vitamin D3 (cholecalciferol) 1,000 IU softgels support calcium absorption, strong bones & muscles, and immune health. GMP-made & 3rd-party tested.*
Vitamin D3 1,000 IU Softgels (180) | Bone & Immune Support
