Vitamin D-3 125 mcg (5,000 IU) — 90 Capsules — Bone, Muscle & Immune Support*
High-potency Vitamin D3 (cholecalciferol) to support calcium absorption, strong bones & muscles, and healthy immune function. Delivers 5,000 IU per softgel — an efficient option for adults working with a clinician to correct or maintain vitamin D status. Produced in FDA-registered, GMP-certified facilities and 3rd-party lab tested for identity, potency & purity.*
Research-Driven & Verified Product.
Explore the clinical research, ingredient science, and global evidence supporting this product below.
Research Promise: At LifeSource Vitamins, our commitment is rooted in research and results. Every benefit below is supported by human clinical studies indexed in the National Institutes of Health (NIH) via PubMed, with full texts available in the National Library of Medicine (NLM) PubMed Central (PMC) when available. In addition, we reference reviews from leading health organizations and insights from top global universities to ensure our guidance aligns with credible science.*
Clinically Studied Benefits
✓ Supports bone mineralization & calcium absorption — Vitamin D3 increases intestinal calcium uptake; deficiency correction improves skeletal outcomes in at-risk adults.
NIH/PubMed — 2020
✓ Helps reduce falls & supports muscle function (older adults) — Trials/meta-analyses report improved lower-extremity function and lower fall risk with adequate vitamin D status.
NIH/PubMed — Gillespie, 2011
✓ Supports immune function / respiratory benefits — Patient-level meta-analysis of RCTs: vitamin D supplementation reduced acute respiratory infection risk, with greatest benefit in those deficient and with regular (not bolus) dosing.
NIH/PubMed — Martineau, 2017
✓ Parathyroid (PTH) regulation — Correcting low 25(OH)D lowers secondary hyperparathyroidism, supporting bone turnover balance.
NIH/PubMed — 2020
✓ Cardiometabolic markers (adjunct) — Evidence suggests potential improvements in endothelial and inflammatory markers in some groups; results vary by baseline status.
NIH/PubMed — 2021
✓ Mood (adjunct) — Meta-analytic and clinical data indicate vitamin D may help mood regulation in deficiency; heterogeneity exists across trials.
NIH/PubMed — 2020
✓ Cancer outcomes (adjunct) — Large RCTs show no reduction in overall cancer incidence, but pooled analyses suggest possible lower cancer mortality with supplementation.
NIH/PubMed — 2018
✓ Bone health across the lifespan — Adequate vitamin D prevents rickets/osteomalacia and supports peak bone mass accrual when combined with adequate calcium/protein.
NIH/PubMed — 2021
Additional / Promising Evidence
✓ Autoimmune modulation — Observational and early interventional evidence suggests vitamin D sufficiency may be associated with lower autoimmune disease activity; confirmatory RCTs ongoing.
NIH/PubMed — 2019
✓ Blood pressure (adjunct) — Mixed RCT data; potential effects via renin–angiotensin modulation.
NIH/PubMed — 2021
✓ Glycemic control / diabetes risk — Large RCTs show neutral primary outcomes overall, with exploratory benefits in participants with low baseline 25(OH)D.
NIH/PubMed — 2019
✓ Joint & inflammatory symptoms — Mixed evidence for symptom improvement via immunomodulation; benefits may depend on deficiency correction.
NIH/PubMed — 2022
✓ Colorectal adenoma (risk markers) — Some trials report favorable effects when combined with calcium; results vary by population.
NIH/PubMed — 2014
✓ Cognition & fatigue (adjunct) — Signals for cognitive and vitality benefits in deficient adults require further high-quality RCTs.
NIH/PubMed — 2022
University-Led & Academic Studies
✓ Supports bone strength & mineralization — D3 (800 IU/day) + calcium reduced hip and non-vertebral fractures in older women in a landmark randomized trial.
NIH/PubMed — Chapuy, 1992
✓ Enhances calcium absorption — Controlled human studies show D3 repletes 25(OH)D and improves fractional calcium absorption, a key mechanism for bone health.
NIH/PubMed — Heaney, 2003
✓ Helps prevent falls in older adults — Meta-analysis of RCTs found vitamin D (≈700–1,000 IU/day) reduced fall risk versus control.
NIH/PubMed — Bischoff-Ferrari, 2004
Global Evidence & Reviews
✓ NIH ODS Vitamin D Fact Sheet (Health Pros) — Evidence, dosing, and safety overview for clinicians.
NIH/ODS — Vitamin D
✓ Harvard T.H. Chan School — Educational review on vitamin D and health (bones, immunity, chronic disease context).
Harvard — Vitamin D
✓ Johns Hopkins Medicine — Patient-level guidance on vitamin D and immunity.
Johns Hopkins — Vitamin D & Immunity
We monitor research from leading institutions —
Harvard, Johns Hopkins, Mayo Clinic, Cleveland Clinic, Cambridge, Oxford, Stanford, Yale, Tufts, University of Florida, Oregon State University – Linus Pauling Institute, Columbia, Cornell, Ohio State — to align with credible science.*
Key Ingredients
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Vitamin D3 (Cholecalciferol) — Supports calcium absorption, bone & muscle function, and immune health. (NIH/ODS — Vitamin D)
Brief Benefit Bullets
- Supports calcium absorption & bone mineralization*
- Helps maintain muscle strength; supports fall-risk reduction in older adults*
- Clinically shown to support immune defenses (especially if deficient)*
- Adjunct support for cardiometabolic and mood markers in select groups*
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3rd-party lab tested for identity, potency & purity
Suggested Use
Take 1 softgel every 2–3 days with a meal, or as directed by your healthcare professional. Individuals targeting specific blood levels (25(OH)D) should test and personalize dosing with their clinician. Do not exceed recommended intake.*
Product Specifications
• Serving Size — 1 capsule
• Vitamin D3 (cholecalciferol) — 125 mcg (5,000 IU) per softgel
• Servings Per Container — 90
• Form — Softgels
• Free From — Non-GMO, gluten-free, no artificial colors*
• Quality — Third-party tested for identity, potency & purity
LifeSource Vitamins — Proudly American — Since 1992
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Vitamin D3 5,000 IU capsules for targeted repletion and maintenance of healthy vitamin D levels — supports bones, muscles & immune health. Clinically Studied Ingredients — NIH/PubMed!*
